I'm looking for a good laptop backpack, right now I have a Tom Bihn Brain Bag (which I love) but it's far to large when I don't have to pack clothing, and organization isn't that great in there.

Typically I need to fit:
15" Retina MBP
iPhone 7Plus
10" iPad
Bose Noise Cancelling Over Ear Headphones
An Assortment of Cables
Medication
Business Cards
Water Bottle

...and want to keep it organized because I take it everywhere with me when I'm onche road.

If I could fit an overnight change of clothes, even better.

I was looking at the Tumi Alpha2, Briggs & Riley @Work, Tom Bihn Synapse

They all seem to be pretty popular and I'd love some input.