I think the best thing I learned from 16 years of long, distant business trips around the world was that you don't have to jam-pack your days and nights just because you flew a long way to get to your destination. When I started out (and for a good 10 years) I would cram in as many meetings, business meals etc. as I could, just because I felt like I was spending a lot of my employer's money to get to X place, so I should really do as much there as humanly possible. Eventually I realized that this was seriously burning me out. I ratcheted back from 6-7 meetings a day to 4-5, and started saying no most of the time to people who wanted me to do things like breakfasts and dinners. My travel life was much improved, as was my general outlook, health, and energy level.