LHR to LAS (and vice versa) can be a mixed bag. I have had some great flights in Club and WT+ and I have had some less stellar ones. BA at its inconsistent best
If you are flying LHR - JFK on a 747 then any seat on the upper deck would arguably be the best! Some are better than others (62 A/K or 64 A/K for example) but there really isn't a bad seat upstairs!
Oh, and this is my 1000th post here in FT. Just sayin'