Issue in DEN is one long terminal walk. It's not that bad, IME, but if you end up arriving at the very end of the RJ gates, it can be a bit of a walk.

50 minutes, assuming your inbound is on time, should work fine as long as you walk at a reasonable speed. The complicating factor could be a late arrival. I probably wouldn't do under an hour these days, especially given I'm usually traveling with a toddler which slows down the walk. But I'd also consider what alternative options are - if you are going to a place where there aren't additional options that day, I'd err on the side of booking a longer connection. That would be different for me than connecting in DEN to say, SFO, where there are lots of additional options if you miss it.