I always select 2K, partly because I am right-handed, and it just feels right. I will say, however, that window seats suffer from the curvature of the A380, which is quite noticeable when sitting - not in a claustrophobic kind of way, but really noticeable. Forget looking out the windows, as they aren't really positioned to easily watch the sky go by (plus, you'll likely want to close the shades within 30-45 minutes after take off).
On my next flight from LAX to DXB, I'll likely select a center seat on the left side of the aircraft (again, the right-handed thing) in the second row. The feeling is much more 'airy' than a window seat - I wouldn't worry about a neighbor, as the dividers are quite substantial.