Not luxury but a historic hoot on the Eel River, comfortable and fun, in Garberville near the Redwoods, for maximum comfort, go for higher-end rooms.
The Benbow Inn
http://www.benbowinn.com/
On Hwy 1 just north of Gualala in Mendocino County:
St. Orries
http://www.saintorres.com/
Again, not luxe but delightfully unusual, comfortable, and the restaurant is great. Book high-end rooms.
In Marshall on Hwy 1 on Tomales Bay (near Point Reyes National Seashore), Nick's Cove Cottages:
https://nickscove.com/
Boonville in the Anderson Valley -- Boonville Hotel, very hip, good food.
http://www.boonvillehotel.com
Again, I stress these are not luxury establishments but rate high on the delight scale.