I've been to Tavern on S inside the food hall and it's very good - fun, casual international cuisine at reasonable prices, US craft beers on tap, decent service, a flashy dining room and a lively atmosphere. There's also a standup bar if you just want a quick drink. Sawamura is also quite good - the original bakery is in Hiroo.
There's a branch of Blue Bottle Coffee downstairs and another third-wave coffee shop up on the second floor. Like most projects from JR East, it's put together very well, and they haven't fallen back on a cookie-cutter shopping-mall template - it's fairly original.
Upstairs from the food hall is a long-distance bus terminal with arrivals all day and night, which is one reason for the extended hours.