Whenever I stop over in Sao Paulo and have a long lay over (at least 8 hours) I do go out BUT I know my way around very well and don't need to pick up my luggage and recheck it. Example, if I arrive in GRU from SCL on LA750 at 13:30 and have a connecting flight with JJ8084 to LHR at 23:45, I'd go out and make sure to head back to the airport at around 19:30. I've done it many many times and never had a problem. You do feel like you've utilized your time very well. However, when I only had 4 - 6 hours layover, I stayed at the airport. As you're flying with LATAM, LATAM has an excellent VIP lounge right opposite the duty free shop, going up the stairs. It's roomy, plenty of good food and drinks and a sleeping area if you're interested, so I wouldn't bother with going to a nearby hotel, which is nothing to call home about and will be expensive anyway. That's it in a nutshell and I'll be happy to give you more info if you so desire. Safe Travels!