One caveat about Priceline in central San Francisco: Last year, PL took three separate San Francisco zones and combined them into a big single zone, making it much more difficult to "pinpoint" possible or likely hotels.
Therefore, you need to carefully consider the new hotel lists on betterbidding.com and on BFT before placing your bid.
I second the recommendation for betterbidding.com as the site to use if you need pro-active bidding assistance.
Just an FYI - for several weekends in June the Nikko (across the street from the SF Hilton) is listing double-bedded rooms for $159...