Originally Posted by
Letitride3c
carsnocean - the drive from EWR to ITH is 4.5 to 5 hours, factor in one stop for bathroom, food/snacks/coffee & fuel - "Waze" your way toward I-80 West, I-380W then I-81N, etc. Most urban traffic should be behind you once past Morristown, NJ - depending on day of week & start time from car rental. Drove this route but with our starting point in NYC last month, left at 6:15 AM on a Sunday & traffic was very light - some highway construction on I-81 (an easy drive but not as scenic ... last drove this 20 years ago, LOL) ... on this popular trucker's route - vehicles moving above the posted speed limit mostly, 70 mph in a few stretches in PA.
On summer weekends, not unusual for parents with teens making pilgrimage trip to see universities and checkout campus & off-campus housing, etc. or even start hauling trailers worth of furnishing on the highway, no matter which way you decided to fly into & aim for the colleges dotted all over the NY landscape. With the limited inventory of hotel rooms, especially on weekends - if you find something, book now & lock it up first while you hunt for a better/free deal.
Otherwise, BUF might be worth considering, especially if your points can be used to book a nonstop - drive is about 3 to 3.5 hours, shorter than EWR for sure but on tolled NYS Thruway, traffic will be buzzing along around 70 mph (just stay with the "pack" to avoid getting singled out & pulled over by the flashing red.) A long, boring drive - especially if you are tired & not fully rested ... on our return trip last month, took us far longer than planned with the ladies in the minivan taking too many restroom stops

in a light rain.
Cornell commencement is the Sunday of Memorial Day weekend. If the OP will be flying in that Friday or Saturday, then the drive from Newark to Ithaca could be nightmarish. I wouldn't do it.
Also, we don't yet know whether the OP plans to go directly to Ithaca upon landing somewhere, or if he plans to check into his SYR hotel first.