Moderator: Hawaii-based airlines & Hawai'i forums
Join Date: Mar 2003
Location: Ka ʻĀpala Nui, Nuioka
Programs: NEXUS/Global Entry, Delta, United, Hyatt, IHG, Marriott, and Hertz
Posts: 18,726
Don't want to confuse you, but let me suggest this route
The 405 is gonna be pretty bad on a Friday evening. As stated above, La Cienaga is a good alternate that runs North-South and will take you into West Hollywood (I also noticed someone gave you directions to North Hollywood - please be advised that North Hollywood is nowhere near West Hollywood and is the San Fernando Valley).
From Hertz, La Cienaga is a few blocks East of the lot, near the 405. Manchester is the major street to the North and Arbor Vitae to the South from Airport Blvd.
Otherwise, I'd suggest getting on the 405 at Sepulveda and Howard Hughes and bypass a bit of the traffic.