i used to insist that i break up a 24 hour journey into 2x 10 hour flights: southern africa to east coast us.
then one time i was booked jnbjfk (15.5hrs nonstop) and i was all like angsty before hand.
but i had a lovely flight that i slept on. then i got off the plane in nyc and was happy. one flight and i was there.
so ya. nonstops.
or shortest first then longest last. nothing's more angst-worthy than lots of flying and one final 2hr flight.