If you can target a group for ads, you can also target a group to NOT send ads - this would save you a bit if you were buying ads.

On the other hand, you could try to craft an ad that appeals to people who don't like ads - perhaps an ad for an Ad Blocker (which would be a bit ironic)

But, for your personal Facebook Experience, if you don't like something - a Post, an Ad etc - you can tell Facebook to not show you stuff. I've spent time hiding crap posts and stupid surveys from apps and sites my friends post, and my feed is much cleaner as a result. Same for ads.