The question is where are you located, and where will you be going en route? That determines whee you may be able to get good exchange rates (domestic U.S banks are said to be horrible).
If you can't get €, try CAD. No problem exchanging it in banks in the middle of nowhere in Cuba (really, my wife and I exchanged for well over CUC 1,000 April last year). Just me sure you can get clean new notes with no tears.