Originally Posted by Zorak

Regarding the Yosemite portion, the last time I did a road trip in this area I left Lake Tahoe around 5:30 AM and reached the eastern entrance of Yosemite around 8 AM.

I would definitely try to stay overnight in Yosemite to allow seeing more sights/at a more leisurely pace, but if you can't find any suitable lodging in it or nearby, depending on your tolerance/endurance for driving you could conceivably leave Tahoe, spend most of the day at Yosemite, exit to the west in the evening, and stay overnight somewhere on your way to CA152 all in the span of one very long day.