As a reasonably tall fellow, I much prefer the middle seat, if we're talking bulkhead/exit row. Especially on widebodies.
http://www.seatguru.com/airlines/Ame...777-300_ER.php
So, on this plane, if for example the only two seats left were 16B and 37C, I'd pick 16B in a heartbeat.
I'd think a little longer if 37B was also available, giving a little elbow room, but I'd still pick 16B.
It's a different story on the narrowbodies. There I'd probably go for an aisle seat. As it's far less of a benefit to be bulkhead, especially on pmUS planes.