I have X10 all over the house and, for the most part, it plays nice. I do have some minor issues from time to time, but I'm relatively certain it has more to do with poor wiring than X10 and HomePlug interacting (mainly since I had issues with X10 alone prior to HomePlug being added). The MOCA side shouldn't be affected at all (also have a Bolt and 2 x Minis) since MOCA operates over Coax cable.