If you're seeking comfort in a business or first class seat, I'd look at American Airlines JFK-LAX. They operate those with an A321 subfleet with three class service, horizontal flat 1 X 1 suites in F, 2 X 2 in J, and 3 X 3 Economy (including 34-36" seat pitch Main Cabin Extra).
IFE flown that or JFK-SFO in J and F and these are very good flights - certainly as good as any widebody on the route.