Thanks, Nigos. The U122CX looks like a really solid choice for a domestic bag. It seems to make good use of the interior volume and the compression mechanism is cool. The guarantee, of course, is great. My concern is whether it will fit, say, Lufthansa or Air Canada sizers.
I'd guess few GAs would question it, but I wouldn't want to invest in a nice bag like this only to find that some *A partners are cracking down and sizing anything that looks iffy.