I love the Serrano! Operated by the Kimpton Group, so small, boutique style property in an older building. Rooms are a bit on the small side, but very nice. The restaurant, Ponzu, does great drinks and appetizers, but I don't think dinner is as good. It is true that it is on the border of a bad neighborhood, but nothing to worry about. The doormen can easily direct you to Union Square, etc. Easy walk to Chinatown, too. I'd definitely stay there.
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