I have taken Larium each time I visited Africa. I noticed I felt "warm" after taking each pill the first trip, but there were no other noticeable effects. I did not notice anything my next trip. I keep my immunizations reasonably up to date: tetanus, hepatitis are the ones that come to mind.
I spent one night at the Victoria Falls Hotel and really enjoyed. It is worth visiting the hotel just to have tea and look around. It is like a museum in many respects. The rest of the falls felt quite touristy but I enjoyed my one day there. We took an ultralight flight over Victoria Falls. It was nice but unfortunately the Falls peak in March and were rather low in August.