1: Book Early. Prices don't go down closer to departure, they go up.
2: Book your seats. Second nature to FF'ers, but infrequent travelers still mistakenly think there is a logic airlines use when THEY pick your seat.
3: Avoid every line you can. Print BP at home, never check bags, get taxi's at the departures level instead of the arrivals level, board early.
4: Be careful about what you eat and drink, even in your own country. Bring immodium and laxatives.
5: Never trust any strangers that approach you, especially if they want to show you around, take you out for a drink, etc. You pick who you interact with.
6: Photocopy your passport, in case you lose your actual passport.
7: Travel on light days..mid week, later flights.
8: If you can get to a city's smaller airports, use those. Less crowds, easier access etc.
9: Don't fly WN. EVER
10: Remember that whatever you eat on the day of, or the day before, a long flight is what you will be dealing with DURING the flight. Eat light, and safe.