The Sofitel Tokyo is just across Shinobazu pond (part of the park/zoo area) from Ueno Station. I think it may be the best hotel (most stars) in the area. Along the east/northeast edge of the park are the museums. Besides the Tokyo National Museum some of the other museums in the area are the Orient Museum, the National Science Museum, the Shi-ta-machi Museum (showing what Tokyo used to be like in the past), the National Museum for Western Art (painting and sculpture from the Renaissance on) and the Tokyo Metropolitan Fine Art Gallery. You're also a few train/subway stops from Akihabara (the retail electronics district) and Asakusa, with its Asakusa Kannon temple and main street of souvenir stands.