Just completed PDX-MSP in F on the E175 in 1A. Not bad at all. Bulkhead leg room was aplenty and other than turbulence preventing a more timely retrieval of my backpack in the overhead bin, it's still a very nice seat.
I must say the one downside of the single-seat side of the aircraft is the smaller overhead bin. Useless except for purses or coats or very small briefcases/laptop bags.
I'm flying back in 2A, so will compare. Generally agree that it's better to have access to bag underneath seat in front, so get the choice.
Like this aircraft a lot, however.