I've always found it difficult to work on board.
Typically, when I've needed to work when travelling, I'll focus all my lounge time on working. If I need to do a bit more to finish on board - prior to the first meal service - then fair enough, but I just can't concentrate on work in the air as well as I can on the ground.
That said, I have always liked the me-time when travelling (alone on business). Some edible food, IFE and BA cabin crew who are extremely adept at re-filling my wine glass means I'm in a very comfortable state, and not one that's conducive to working after a couple of hours in.
Therefore I think my attitude to work on board is kind-of circular, linked to quaffable wine.