You will have no language problems, most people in Prague speak English and it is a required language in grade/high school.
On our last two vists (2weeks and 3 days) we rented an apt. one block off of Tram #22 (goes to all important sightseeing areas). Two Bedroom apt was $65US, full kitchen, bath (tub and shower), living room and TV room. If interested email me and I will give you the rental agency info.
Best guide book we found was "Eye Wwitness Prague", try Amazon.com
On our first trip we found trains and busses so cheap we used Prague as a center and did "Day Trips". Buses were $4US R/T to Kunta Hora and about the same to Kala Vary.
Prague is my favorite Eastern Europe Cities and one of my all time favorites.
Have a great time.