Hi yevlesh2,
You should be able to get by quite easily in Prague even if you don't speak any czech. Many people there speak enough english so that you can get by without much difficulty. I can personally recommend the Hilton in Prague. It was fabulous. I understand that there are many other decent hotels there too, but I've only stayed at the Hilton. Be sure to see both sides of the city, the palace side and the side with the Tyne church. The Charles bridge is worth a look-see. Have a great trip.