I stayed here for 1 night over Thanksgiving, having previously spent 3 nights at the W Istanbul.
The St Regis Istanbul met my expectations as a St Regis. Check-in was smooth and easy. As a SPG Platinum member I'd been upgraded from a base room to a "Grand Deluxe" room - top floor, view of the park with an outside space with chairs and a table. The room was very nice, not as big as the room I'd had at the W (upgraded to Fabulous suite), but big enough for my needs. My butler spent a long time explaining all the amenities of the room and the various controls (which was nice, because at the W I spent far too long trying to figure out how to turn all the lights on and off). Fresh fruit and tea were delivered and I sent off a few items to be pressed for the evening.
In the evening I went to the lobby bar for the "evening wine ritual", I got there just after 7 when it was supposed to start and it was empty. I'm not sure if it started later or not, but I went for dinner in the Brasserie. Food and wine was good - they had a Thanksgiving menu, but I opted for the regular menu.
I slept well in the room. Beds were comfortable and the shower was excellent.
I didn't try breakfast as the fruit in the room was sufficient and the nespresso machine was all I needed for coffee.
Checkout was efficient, he noted it was my birthday and wished me a happy birthday and said that they would have gotten me a cake if I'd been staying that day. Meanwhile it seems every member of staff in the lobby had been informed, included one of the managers as everyone individually wished me a happy birthday.
All in all, very comfortable. Would I stay again? Probably, although rates at the W are probably better.