If you can get a 4 wheel drive car or SUV, I would recommend it. From the weather forecast I just checked online, snow is predicted for next weekend. Yes, the drive to Seward is beautiful... but winter weather definitely adds an additional level of difficulty. Not sure if you have experience driving in snow, but winter driving in Alaska can get tricky. Anchorage to Homer is a pretty long drive - approx 4 hrs. For such a short trip, I don't think I would do it.