It's probably going to be chilly, raining, and dark. We can definitely have some breaks in the rain, but I would not count on it. It doesn't pour down rain and storm often, but drizzles a lot.
As for those areas, do you mean Cascade Station? Also, east Portland can mean a lot of things - from great to places I really wouldn't bother staying. Any specifics?
What do you plan on doing? Some activities are pretty pointless in the winter, though others will be fine.