For highway driving and anything that requires driving outside a city - nothing beats a good old fashioned map - aligned to your travel direction and not to the North.

In the city a combination of directions from MapQuest (or similar other) and a detailed map to help when your route is backed up. The Neverlost has been great in most places, but for some reason in the NJ area I always get one that goes haywire and shows exits that don't exist or are off service roads and so on.