You are going at it the wrong way. The first thing you should do is set some clear goals about what you want - miles, hotel points and or cash back. If your goal is miles and points, then get clear about which programs you want to accumulate in. If you don't have clear travel goals, then you should go for maximizing cash back.

With an $100K spend you can easily amass lots of miles and points. But if you don't have clear goals then you can easily waste a bunch of credit card applications and end up with a pile of miles and points you can't use.