I did weekly LON - IOM commute for 3 months back in 2003 (which got me my BAEC Silver card and into "all this").
Also did weekly LON - BHX for 9 months last year.
Neither were great for work/life balance and "having a life" and I think it's key to build a 'double life' in the other place, i.e. find things / do things that make you feel 'at home' (local friends, gym, cinema, etc) rather than just becoming Alan Partridge.....