Having just spent 2 years in Louisville, have to agree with all of the above, especially about BBC on Shelbyville road.A great "hole in the wall" place is the Come Back Inn, which doesn't look like much but is a great Italian place. Its always full so if you go be prepared to wait. http://www.louisvillehotbytes.com/comeback.shtml
The Doubletree is within a couple of blocks of the Hyatt. When I stayed there just after I arrived in Louisville everyone advised me not to walk around there after dark. (Though on general Louisville's a safe place)

If you want something to do there's always the Slugger museum downtown where they'll customize bats for you (neat gifts).

For a great view of Louisville, cross the bridge into Indiana and try Buckheads (not the greatest food, but some of the best views from the deck).
Hope this is of some use, email me if you want more info

Louise