Upgrades are valid for one class of service.
On AA, Main Cabin or Main Cabin Extra to Business internationally or three class aircraft / First domestically. Main Cabin Extra is not a separate class of service, merely Main Cabin with extra seat pitch.
BA and some other airlines offer four classes of service on some aircraft. Generally, Economy, Economy Plus, Business and First. On BA, an upgrade from economy / World Traveller is to economy plus / World Traveller Plus (or from World Traveller Plus to business / Club World).