If you're looking for something a bit different to G-A-Y check out Dalston Superstore on Kingsland High Street in the East End.
Fitladz at Barcode on Fridays nights could also appeal to you. Vauxhall clubbing so a bit different to Soho though...it's not uncommon to leave the clubs in the early afternoon after the night before...
Fire also has a great Sunday night/Monday morning club night - it's not fun/pretty when you forget your sunglasses at your hotel when you have to brave the tube at 11am after 23 hours of partying!