Could you be a little more precise? Will you be paying for business and hoping for an upgrade to first? I think in terms of airline quality you have a lot of choice, including any number of European and ME carriers. You could also do the Delta or SAA flights from US to JNB, but quality will not be the same. Not to rain on your parade, but no airline is going to roll out the red carpet for a 4x per year traveller. You're not adding a great deal to the bottom line.