Hi Jer,
Sorry to hear you're having problems. I have never expperienced the mouse problem you describe.
I have occassionally experienced quirky behavior, especially on my home Win 2k machine which I only reboot when absolutely necessary (e.g., the app has, on rare occassions stop responding to clicking on links).
I hate to sound like a bad tech support guy, but in those instances of quirkiness, a reboot has cleared it up.