Nice itinerary! A couple of thoughts:

Addo: it looks like an overnight at Addo? If so, I'd highly recommend staying onsite, preferably in a rondavel. Details at http://www.sanparks.org/parks/addo/t...ommodation.php (B'n'bs are generally a distance away.)

Also, after hiking at Tsitsikamma. the drive to Addo is fairly long which could influence what you do at Addo. Better yet, stay more than one night if you can to benefit from night drives as well as day drives.

If time is short, consider a one way rental from CT to Port Elizabeth - commonly done and not expensive - and a one way flight from PE to CT at the end. IMO a better use of time.

I find driving in SA pretty easy, as long as you remember that (most ) traffic drives on the left. I've given up using manual transmission and now go for automatics, more expensive but less strain.