Been commuting like this for nearly 15 years! Yes, it wears thin and is tiring, especially if you have a door-to-door commute of nearly 10 hours at each end of the week, as I often do. Also doesn't help when companies like BA tinker with their frequent flyer scheme to make it less attractive to frequent flyers.
But you do get into the routine of it and if you can work from home on a Monday or Friday, it makes the whole thing more bearable.
You will not be alone.