Some of my old bosses in London used to commute from Southern France via Nice. In by Monday lunchtime and leave early on a Friday afternoon. They loved it, but all had nice apartments in central London to go to and a sense of a settled life in the city.

I do a sort of half-commute to Singapore once a month or more, and i found the way to make it bearable is to get yourself a routine. Same hotel, same route to work, same restaurant every night etc. In other words, do the things you would do if you lived there.