At age 54 I commuted Lon to Holland for 3 years, out last flight Sun, back last flight Fri (and by last flight I mean watching Concorde leave LHR for NY at 8 pm, arriving in my Hague flat at midnight, and getting home on Friday between 11 and midnight). To save (my) money I ended up using Rotterdam which meant a CityFlyer ATR, so often a rough flight at low altitude during the winter. With mid-week business trips to other places I averaged 130 BA legs per year, plus others with KLM. This was followed by 2 years of Mon-Fri commuting to Newcastle, and then 4 years Mon-Fri to Aberdeen. I survived, so did my marriage, and so can you.
The musts are :-
Lounge access to handle the delays.
A flat, not a hotel. This keeps you busy in the evening, cooking, washing ironing etc, otherwise it's drinking too much in a bar & watching rubbish TV from a hotel bed.
A wife that understands it's necesssary for the job, not your choice.
A wife that has, or developes, other interests. Mine didn't mope at home but took on courses on woodwork, table tennis, Italian, Yoga & went to the theatre a lot. The most difficult part, is that when the commute ends after 9 years away, the home re-entry is very difficult. You can't just waltz in expecting dinner, she will have got to like her other interests & will be (still is) keen on them.
The weekends are tough, the little jobs you would easily do in the evenings, all have to be done at the weekend but under a time-constaint, and it will rain when you try to go out, or have to cut the grass before your flight.
But, you may get Lifetime Gold & a lot of Avios, just in time for BA to de-value them, if you can find redemption availability that is ! I used to think BA were a bit special to fly with, I now fly a lot less and don't look forward to it.