As mentioned previously it depends on the location. Here's my general approach in most places:

I carry on my person at all times my passport, enough cash to get to the nearest major airport by taxi and credit/debit cards with sufficient room to get me a walk-on flight home. If I have to go home on the spot I don't need to go back to my hotel room or stop for any reason.

In my hotel room safe are a spare debit and credit card, some additional cash and copies of my passport and DL. If I'm in transit they go into a compartment of my personal item carry-on or into a neoprene ankle wallet that I use in rougher places.

All of the relevant local numbers are written down and on my smart phone.

Medical insurance is in place and while I might have antibiotics I've never needed to use them despite many trips to developing countries. YMMV.