I've found myself preferring Five Guys more than In-N-Out lately. That's partly because I live down the street from the latter and got sick of them at one point, but also because I like the topping choices at FG a lot better. I usually get "everything + BBQ" and it turns out good. Oh, and the cajun fries are miles better than In-N-Out's fries too. ^

That said, FG costs a fair bit more and is farther so In-N-Out wins most of the time whenever I feel like a burger.