Wow, so you are planning on landing at 6am on a Monday and going to work/school. Have you flown on +15 hour flights before? Not a possibility for me, but go for it. Going to be a long day.
That being said, March in Cape Town and Botswana, is glorious. Follow Craig's advice. I think that even though you are used to fast paced travel, once you get to Southern Africa, you are going to want to slow down and really savor the experience. I would recommend trying to do less as opposed to more. My preference is more time on safari, Victoria Fall is amazing to see and experience, and many fun things to do in and around Livingstone/Vic Falls.
Enjoy, it will be a trip of a lifetime, or maybe the first of many trips of a lifetime.