Assuming you get an unrenovated A333 on CRK, there is a substantial difference in the seat comfort because the unrenovated A333 seat is angled lie-flat whereas the 77W is fully flat. If you find it difficult to sleep on angled lie-flat seats, and you wish to sleep on that flight, that will be something to bear in mind.

But if choice between connecting in a not-so-nice airport to a domestic flight or non-stop directly to CRK, I would probably choose the non-stop to CRK, especially if it is cheaper as well.