The former Suntrust Building (formerly the CCB Building) downtown has been renovated into the boutique luxury 21c Museum Hotel:
http://www.21cmuseumhotels.com/durham/
It's certainly a different concept:
As North America’s first museum devoted solely to art of the 21st century, 21c Museum Hotel is committed to featuring a rotating program of thought-provoking solo and group exhibitions that reflect the global nature of art today, as well as site-specific, commissioned installations.
21c was founded by Laura Lee Brown and Steve Wilson, contemporary art collectors and preservationists who have a passionate belief in the power of innovative and thought-provoking art to transform communities. Brown and Wilson founded 21c with a mission of broadening the audience for and deepening appreciation of contemporary art.