I can't wait to see what you all think. I am leaning towards flying Cathay Pacific but don't know which one world account to put the miles into (CX, AA or other). I do plan on getting a Chase Saphire CC as well (and possibly AA cc too if AA is the dump site) I plan on over $60k in purchases a year. I wish I could fly Virgin Atlantic due to the wide seats in premium economy but they only fly to Hong Kong so that's out.

Questions
For members asking for information, to help people to assist you, can you please provide:
(1) What is most important to you in a FFP?
(upgrades on travel, priority services when flying the airline, extra baggage allowance, good award redemption rates, better award access, free - discounted lounge access, etc.)
Reply: I am looking for comfort first i.e. lounge access, shorter lines. It is really important to move up the tiers as fast as I can. Second EASY miles redemption for free airfare all over the world for me and my family.
(2) How many miles do you usually fly each year & in what class? How many flights/sectors?
(<25000, 25000-50000, >50000 miles - <25, 25-50, >50 flights?)
Reply: I would say over 150k miles per year and 50 flights.
(3) What types of fares do you usually buy?
(First, Business, Premium economy, Economy, cheapest)
Reply:All premium economy.
(4) Can you choose your airlines and/or class of service? Do you travel for work and/or pleasure?
Reply:All work travel. I have free reign over what airlines but only premium economy.
(5) Which routes and airlines do you fly most often?
(US Domestic, Transpacific, Kangaroo, in Asia etc)
Reply:Transpacific and inter asia
(6) What is your home airport?
(SFO, SCL, London LHR, HKG, Singapore SIN etc.)
Reply:SFO
(7) Do you have FFP status of any kind in OW or other airline? What is it? Do you have any miles banked in a FFP?
(AA Executive Platinum, QF Gold, UA 1K, LAN Comodoro, etc)
Reply:Nothing. Starting from zero so speed is important moving up.
(8) Preferred Airlines? Most common Airlines flown on?
Reply:Virgin