"Next flight is a Delta 747-400 from ATL to HNL. Does Row 22 have decent leg room? Looks like there's a bathroom in front (which concerns me a bit)."

Row 22 has lots of leg room. The aisle seats of row 22 would not be my preference because you are very close to the toilets. The bulkhead wall extends from the window to a little past the middle seat, leaving the aisle seats with more leg room since the bulkhead wall doesn't extend that far.

If you must have an aisle seat, I would not choose Row 22. If you like window seats, row 22 is the best, and if there are two of you, the middle seat is not bad either because it is easy to get out due to the large amount of legroom in the first EC row.

The reason I would not choose row 22 if you need an aisle seat is because of the toilet. I've sat on that plane in row 23 aisle and could smell the toilet. Of course, it was on longer international flights, 14+ hours, as compared to the 9 hour Atl-Hnl flight. So...you might risk it. Good luck. Hope this helps.