This is about the point where I would have politely told CBP that I was a US citizen, they were welcome to search my bags, and beyond that they could go [moderator edit] themselves. My family and religion are irrelevant.
The last time I took this approach with CBP, I made my connection with only about 30 seconds to spare...
I fully agree with you in principle, but everything I read in the US media - think there's been at least five references in the NY Times to US efforts to intercept jihadists over the past year, and I believe it's reasonable to infer that the IAP at European airports is very much a part of that effort - seems to support GUWonder's observation that CBP takes this threat seriously and that I do fit into some sort of profile given the data sources they have at their disposal. Part of me would like to assume that if I was the subject of a serious investigation, the National Targeting Center would note that I charge a lot on my Chase Sapphire card to bars, wine shops and Starbucks in the more secular parts of Istanbul and infer that I'm probably not a brainwashed Manchurian Candidate, but who knows the full extent of what they're doing and how thoroughly they're doing it. Similarly, I would hope that being married to an Iranian would seriously reduce the probability of being a jihadist in their risk models since most of the rebels fighting in Syria would desperately want to kill me and my family, but the fact that one CBP interviewer literally said "she's from Iran, so I guess she was probably born in Karachi, right?" suggests some degree of incompetence on their end. (In fairness, that could have been a trick question directed at me - but again, who knows?) At this point I'd rather be upfront about my situation, even if that honesty potentially puts me into a moderate risk group, than allow CBP to look at my passenger-name-records and whatever else they can get their hands on and construct their own story about what I was doing between flights in and out of Istanbul.